Shortcut Conflict between MPC-HC and madVR

"Ctrl+S" is a popular, old shortcut of MPC-HC which is used for saving downloaded subtitle to the disk. But now-a-days if you clean-install K-Lite Codec Pack and use madVR as video renderer, pressing Ctrl+S brings up madVR settings (instead of bringing up "save subtitle" dialogue as set in MPC-HC options). Please change the madVR settings shortcut prior to packing it in codec pack if you can. Thank you!

I can't change the defaults of madVR. You have to submit a request to its developer:
http://bugs.madshi.net/view_all_bug_page.php

You can adjust shortcuts yourself here:
MPC-HC options > Player > keys
madVR options > user interface > keyboard shortcuts